重离子物理研究所核药物化学组的12

王祥云

doi:10.11804/NuclPhysRev.13.02.060

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重离子物理研究所核药物化学组的12

王祥云

文章导航 > 原子核物理评论 > 1996 > 13(2): 60-61

王祥云. 重离子物理研究所核药物化学组的12[J]. 原子核物理评论, 1996, 13(2): 60-61. doi: 10.11804/NuclPhysRev.13.02.060

引用本文:

王祥云. 重离子物理研究所核药物化学组的12[J]. 原子核物理评论, 1996, 13(2): 60-61. doi: 10.11804/NuclPhysRev.13.02.060

Wagn Xiang-yun. Brief Review of Nuclear Pharmaceutical Study at IHIP[J]. Nuclear Physics Review, 1996, 13(2): 60-61. doi: 10.11804/NuclPhysRev.13.02.060

Citation:

Wagn Xiang-yun. Brief Review of Nuclear Pharmaceutical Study at IHIP[J]. Nuclear Physics Review, 1996, 13(2): 60-61. doi: 10.11804/NuclPhysRev.13.02.060

重离子物理研究所核药物化学组的12

doi: 10.11804/NuclPhysRev.13.02.060

王祥云

北京大学技术物理系; 北京大学重离子物理研究所

Brief Review of Nuclear Pharmaceutical Study at IHIP

Wagn Xiang-yun

Department of Technical Physics; Institute of Heavy Ion Physics; Peking University; Beijing 100871

摘要: 用放射性核素标记抗肿瘤单克隆抗体（ＭｃＡＢ）一直是核药物化学组的研究重点．研究出一个制备超纯无载体１１１Ｉｎ的方法．通过双功能连接剂ＤＴＰＡ环酐将其标记于抗肿瘤ＭｃＡＢ在临床实验中获得成功．用直接标记法制备的９９Ｔｃ标ＭｃＡＢ片段在诊断胃癌方面性能优良．此外，还进行了两种标记法的方法学及Ｔｃ和Ｒｅ的配位化学研究．用加速器质谱计（ＡＭＳ）研究化学物质与ＤＮＡ的加合作用及其遗传毒性是另一个研究方向．已测定过的化学物质有烟碱、烟碱衍生物ＮＮＫ、抗蚜威等，灵敏度达到每１００亿个ＤＮＡ分子中１个加合物.The labeling of anti tumor monoclonalantibodies (McAB) with radionuclides has been regarded as our main aim in the past 12 years. A procedure of preparation of ultrapure carrier free 111 In has been developed. Anti tumor McABs labeled with 111 In via a bifunctional conjugating agent (DTPA cycloanhydride) were used successfully in clinical trials. 99m Tc labeled McAB fragments prepared by a direct method were also proved very powerful in diagnosis of gastric carcinoma...
- 核药物 /
- 放射性标记 /
- 单克隆抗体 /
- 加速器质谱 /
- 遗传毒性
Abstract: The labeling of anti tumor monoclonalantibodies (McAB) with radionuclides has been regarded as our main aim in the past 12 years. A procedure of preparation of ultrapure carrier free 111 In has been developed. Anti tumor McABs labeled with 111 In via a bifunctional conjugating agent (DTPA cycloanhydride) were used successfully in clinical trials. 99m Tc labeled McAB fragments prepared by a direct method were also proved very powerful in diagnosis of gastric carcinoma...
- nuclear pharmaceutical /
- radioactive labeling /
- monoclonal antibody /
- accelerator mass spectroscopy /
- genetic toxicity

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重离子物理研究所核药物化学组的12

doi: 10.11804/NuclPhysRev.13.02.060

王祥云

北京大学技术物理系; 北京大学重离子物理研究所

收稿日期: 1900-01-01
修回日期: 1900-01-01
刊出日期: 1996-06-20

关键词:

核药物 /

摘要: 用放射性核素标记抗肿瘤单克隆抗体（ＭｃＡＢ）一直是核药物化学组的研究重点．研究出一个制备超纯无载体１１１Ｉｎ的方法．通过双功能连接剂ＤＴＰＡ环酐将其标记于抗肿瘤ＭｃＡＢ在临床实验中获得成功．用直接标记法制备的９９Ｔｃ标ＭｃＡＢ片段在诊断胃癌方面性能优良．此外，还进行了两种标记法的方法学及Ｔｃ和Ｒｅ的配位化学研究．用加速器质谱计（ＡＭＳ）研究化学物质与ＤＮＡ的加合作用及其遗传毒性是另一个研究方向．已测定过的化学物质有烟碱、烟碱衍生物ＮＮＫ、抗蚜威等，灵敏度达到每１００亿个ＤＮＡ分子中１个加合物.The labeling of anti tumor monoclonalantibodies (McAB) with radionuclides has been regarded as our main aim in the past 12 years. A procedure of preparation of ultrapure carrier free 111 In has been developed. Anti tumor McABs labeled with 111 In via a bifunctional conjugating agent (DTPA cycloanhydride) were used successfully in clinical trials. 99m Tc labeled McAB fragments prepared by a direct method were also proved very powerful in diagnosis of gastric carcinoma...

English Abstract

王祥云. 重离子物理研究所核药物化学组的12[J]. 原子核物理评论, 1996, 13(2): 60-61. doi: 10.11804/NuclPhysRev.13.02.060

引用本文:

王祥云. 重离子物理研究所核药物化学组的12[J]. 原子核物理评论, 1996, 13(2): 60-61. doi: 10.11804/NuclPhysRev.13.02.060

Wagn Xiang-yun. Brief Review of Nuclear Pharmaceutical Study at IHIP[J]. Nuclear Physics Review, 1996, 13(2): 60-61. doi: 10.11804/NuclPhysRev.13.02.060

Citation:

Wagn Xiang-yun. Brief Review of Nuclear Pharmaceutical Study at IHIP[J]. Nuclear Physics Review, 1996, 13(2): 60-61. doi: 10.11804/NuclPhysRev.13.02.060