Brief Review of Nuclear Pharmaceutical Study at IHIP
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摘要: 用放射性核素标记抗肿瘤单克隆抗体(McAB)一直是核药物化学组的研究重点.研究出一个制备超纯无载体111In的方法.通过双功能连接剂DTPA环酐将其标记于抗肿瘤McAB在临床实验中获得成功.用直接标记法制备的99Tc标McAB片段在诊断胃癌方面性能优良.此外,还进行了两种标记法的方法学及Tc和Re的配位化学研究.用加速器质谱计(AMS)研究化学物质与DNA的加合作用及其遗传毒性是另一个研究方向.已测定过的化学物质有烟碱、烟碱衍生物NNK、抗蚜威等,灵敏度达到每100亿个DNA分子中1个加合物.The labeling of anti tumor monoclonalantibodies (McAB) with radionuclides has been regarded as our main aim in the past 12 years. A procedure of preparation of ultrapure carrier free 111 In has been developed. Anti tumor McABs labeled with 111 In via a bifunctional conjugating agent (DTPA cycloanhydride) were used successfully in clinical trials. 99m Tc labeled McAB fragments prepared by a direct method were also proved very powerful in diagnosis of gastric carcinoma...Abstract: The labeling of anti tumor monoclonalantibodies (McAB) with radionuclides has been regarded as our main aim in the past 12 years. A procedure of preparation of ultrapure carrier free 111 In has been developed. Anti tumor McABs labeled with 111 In via a bifunctional conjugating agent (DTPA cycloanhydride) were used successfully in clinical trials. 99m Tc labeled McAB fragments prepared by a direct method were also proved very powerful in diagnosis of gastric carcinoma...
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